Menu

Soft Tissue Fillers – Addressing Wrinkles and Volume Loss

Medically Reviewed
Medically Reviewed by Dr. Aurora Kalmanson on
Written by Fillers Editorial Team, plastic surgery specialists.

Soft tissue fillers have revolutionized the field of cosmetic dermatology, offering a non-surgical solution to combat signs of aging and enhance facial features. These injectable substances, also known as dermal fillers, have gained immense popularity due to their ability to restore volume, smooth wrinkles, and contour facial features with minimal downtime.

Dermal fillers work by replacing lost volume in the face, which occurs naturally as we age and lose collagen and fat beneath the skin. They can effectively address a range of concerns, from fine lines and deep wrinkles to hollow cheeks and thinning lips. With various types of fillers available, including hyaluronic acid, calcium hydroxylapatite, and poly-L-lactic acid, patients can achieve natural-looking results adapted to their specific aesthetic goals. While not a permanent solution, soft tissue fillers offer a less invasive alternative to surgical procedures, with results lasting anywhere from six months to two years, depending on the product used and the area treated.

What are Soft Tissue Fillers?

Soft tissue fillers are injectable substances used to add volume, smooth wrinkles, and enhance facial contours. They are a popular non-surgical option for facial rejuvenation and contouring.

Definition and Description

Soft tissue fillers: Injectable substances designed to restore volume, smooth wrinkles, and enhance facial features. These gel-like materials are injected beneath the skin to address various signs of aging and improve overall facial appearance. Soft tissue fillers work by physically filling in areas of volume loss or deep wrinkles, providing immediate results in most cases. They can be used to plump thin lips, enhance shallow contours, soften facial creases, and improve the appearance of recessed scars. The procedure is minimally invasive, typically performed in a doctor’s office with little to no downtime, making it an attractive option for those seeking facial rejuvenation without surgery.

Types of Soft Tissue Fillers

Hyaluronic Acid (HA) Fillers: Hyaluronic acid fillers are the most commonly used type of soft tissue filler. Hyaluronic acid is a naturally occurring substance in the body that helps keep skin plump and hydrated. These fillers are gel-like in consistency and are known for their ability to provide natural-looking results. Hyaluronic acid fillers are versatile and can be used to address a wide range of concerns, from fine lines and wrinkles to lip enhancement and cheek augmentation. They are also reversible, meaning the effects can be dissolved if necessary. Popular brands include Juvederm, Restylane, and Belotero. The results typically last between 6 to 18 months, depending on the specific product and area treated.

Calcium Hydroxylapatite (CaHA) Fillers: Calcium hydroxylapatite fillers are composed of tiny calcium particles suspended in a smooth gel. This type of filler is typically thicker than hyaluronic acid fillers and is often used for deeper wrinkles and folds. Calcium hydroxylapatite is a naturally occurring substance found in human bones, which makes it highly biocompatible. One of the key benefits of CaHA fillers is their ability to stimulate natural collagen production, potentially leading to longer-lasting results. These fillers are commonly used to treat deeper nasolabial folds, marionette lines, and to enhance cheek volume. The most well-known brand of CaHA filler is Radiesse. Results from calcium hydroxylapatite fillers typically last about 12 months or more, making them a longer-lasting option compared to some hyaluronic acid fillers.

Poly-L-lactic Acid Fillers: Poly-L-lactic acid fillers are unique among soft tissue fillers as they work as bio-stimulators. Unlike other fillers that provide immediate volume, poly-L-lactic acid gradually stimulates the body’s own collagen production. This synthetic, biocompatible substance has been used for many years in medical devices and dissolves naturally in the body over time. Poly-L-lactic acid fillers are typically used to treat deeper facial wrinkles and are particularly effective in restoring volume to areas of the face that have become sunken or hollow due to aging or weight loss. The treatment usually requires a series of injections over several months, with results developing gradually and lasting up to two years or more. The most well-known brand of poly-L-lactic acid filler is Sculptra Aesthetic. This type of filler is often chosen by patients looking for subtle, progressive improvements in facial volume and contour.

Polymethylmethacrylate (PMMA) Fillers: These fillers consist of tiny, smooth microspheres of polymethylmethacrylate suspended in a collagen gel. PMMA is a synthetic, biocompatible material that has been used in medical implants for decades. When injected, the collagen gel provides immediate volume, while the PMMA microspheres remain in place, stimulating the body to produce its own collagen around them. This dual action results in a long-lasting volumizing effect. PMMA fillers are considered semi-permanent, with results that can last for several years. They are typically used for deeper wrinkles, nasolabial folds, and acne scars. However, due to their permanence, they require careful application by a skilled practitioner to avoid complications. The most well-known brand of PMMA filler is Bellafill.

Autologous Fat Injections: This procedure, also known as fat grafting or fat transfer, involves using a patient’s own fat to add volume to various areas of the face. The process begins with liposuction to harvest fat from areas such as the abdomen, thighs, or buttocks. The harvested fat is then purified and carefully injected into targeted areas of the face. Autologous fat injections can address volume loss in the cheeks, temples, and under-eye areas, as well as smooth out deep wrinkles and folds. One of the main advantages of this technique is its natural-looking and long-lasting results, as the transferred fat can integrate with existing facial tissues. However, not all transferred fat survives, so multiple treatments may be necessary to achieve the desired outcome. This method is particularly appealing to those who prefer using their own tissues over synthetic fillers.

Benefits of Soft Tissue Fillers

Adds Volume to the Face: One of the primary benefits of soft tissue fillers is their ability to restore lost facial volume. As we age, our faces naturally lose fat and collagen, leading to a hollow or gaunt appearance. Soft tissue fillers can effectively replenish this lost volume, particularly in areas such as the cheeks, temples, and under-eye regions. By adding volume strategically, fillers can lift sagging skin, fill in deep folds, and create a more youthful, rounded facial contour. This volumizing effect not only improves the overall appearance but also helps to support the skin’s structure, indirectly smoothing out fine lines and wrinkles. The result is a more refreshed, rejuvenated look that appears natural and harmonious with the individual’s facial features.

Smooths Out Wrinkles and Fine Lines: Soft tissue fillers excel at reducing the appearance of wrinkles and fine lines, providing a smoother, more youthful complexion. When injected into the skin, fillers physically plump up and support the tissue from beneath, effectively “filling in” creases and lines. This is particularly effective for static wrinkles – those that are visible even when the face is at rest. Common treatment areas include nasolabial folds (smile lines), marionette lines around the mouth, and fine lines around the eyes and forehead. By smoothing out these lines and wrinkles, fillers can significantly rejuvenate the face, often taking years off one’s appearance. The natural-looking results and the ability to target specific problem areas make fillers an attractive option for those seeking to address signs of aging without surgery.

Enhances Facial Contours: Soft tissue fillers play a crucial role in enhancing and refining facial contours, allowing for subtle yet impactful improvements to one’s appearance. They can be used to augment and define key facial features such as the cheekbones, chin, and jawline, creating more balanced and aesthetically pleasing proportions. For instance, fillers can add projection to a weak chin, enhance the curvature of the cheeks, or create a more defined jawline. This contouring effect can help achieve a more youthful or sculpted appearance, addressing issues like facial asymmetry or age-related volume loss. Additionally, fillers can be used for non-surgical rhinoplasty, subtly altering the shape of the nose. The ability to enhance facial contours with precision allows for customized treatments that complement an individual’s natural features, resulting in a harmonious and refreshed look.

Minimally Invasive with Little Downtime: Soft tissue fillers offer a significant advantage over surgical procedures due to their minimally invasive nature and minimal downtime. The treatment typically involves a series of quick injections performed in a doctor’s office, often taking less than an hour to complete. Unlike surgical facelifts or other invasive procedures, there’s no need for general anesthesia, incisions, or prolonged recovery periods. Most patients can return to their normal activities immediately after the treatment, with only minor precautions such as avoiding strenuous exercise for a day or two. Any visible signs of the procedure, such as slight redness or swelling, usually subside within a few days. This minimal downtime makes soft tissue fillers an attractive option for those with busy lifestyles or those who cannot afford extended time away from work or social activities.

Risks and Side Effects of Soft Tissue Fillers

While generally safe, soft tissue fillers can have side effects and risks. Most are mild and temporary, but some can be serious. It’s crucial to understand these potential complications and discuss them with a qualified healthcare provider before undergoing treatment.

Common Side Effects

Bruising, Redness, and Swelling: These are among the most common side effects associated with soft tissue filler injections. Bruising occurs when small blood vessels are inadvertently damaged during the injection process, leading to discoloration of the skin. Redness and swelling are natural inflammatory responses to the injection and the presence of the filler material. These effects typically appear immediately after the procedure and can last for several days to a week. The extent of bruising, redness, and swelling can vary depending on the individual’s skin sensitivity, the type of filler used, and the specific area treated. While usually mild, these side effects can be more pronounced in areas with thinner skin or a higher concentration of blood vessels, such as around the eyes or lips. Most practitioners recommend applying cold compresses and avoiding blood-thinning medications before the procedure to minimize these effects.

Pain, Tenderness, and Itching: Following soft tissue filler injections, patients may experience varying degrees of discomfort in the treated areas. Pain and tenderness are common immediately after the procedure and can persist for a few days. The sensation is often described as a mild ache or pressure at the injection sites. Itching may also occur as the skin heals and adjusts to the presence of the filler material. These symptoms are generally mild and can be managed with over-the-counter pain relievers or antihistamines if necessary. The intensity of these side effects can depend on the individual’s pain tolerance, the specific filler used, and the technique employed during injection. In most cases, pain, tenderness, and itching resolve on their own within a week. However, if these symptoms persist or worsen, it’s important to contact the healthcare provider as it could indicate a more serious complication.

Lumps or Bumps (Nodules or Granulomas): In some cases, patients may develop small lumps or bumps beneath the skin at the injection sites. These can be categorized into two types: nodules and granulomas. Nodules are typically small, firm masses that can be felt under the skin and may be visible in some cases. They often occur shortly after treatment and can be caused by uneven distribution of the filler or the body’s reaction to the filler material. Granulomas, on the other hand, are inflammatory reactions that can develop weeks, months, or even years after the initial treatment. They appear as hard, sometimes painful lumps beneath the skin. The risk of developing nodules or granulomas varies depending on the type of filler used, with some materials being more prone to causing these reactions than others. In many cases, nodules can be massaged or treated with enzymes to dissolve them, while granulomas may require more extensive treatment, including corticosteroid injections or surgical removal.

Rare but Serious Complications

Infection: While rare, infections can occur following soft tissue filler injections. These infections can range from mild to severe and may be caused by bacteria introduced during the injection process or by the activation of dormant bacteria already present in the skin. Symptoms of infection include persistent redness, swelling, pain, and warmth at the injection site, often accompanied by fever. In some cases, infections can lead to the formation of abscesses or even spread to other parts of the body. Proper sterilization techniques and adherence to aseptic protocols during the procedure significantly reduce the risk of infection. However, if an infection does occur, it requires prompt medical attention and may require treatment with antibiotics or, in severe cases, surgical intervention to drain any abscesses.

Allergic Reactions: Allergic reactions to soft tissue fillers, though uncommon, can range from mild to severe and potentially life-threatening. These reactions occur when the body’s immune system responds abnormally to the filler material. Mild allergic reactions may manifest as localized redness, swelling, itching, or hives at the injection site. More severe reactions can include widespread rash, difficulty breathing, swelling of the throat or tongue, and anaphylaxis, a potentially life-threatening condition requiring immediate medical attention. The risk of allergic reactions varies depending on the type of filler used, with some materials, particularly those derived from animal sources, posing a higher risk. To minimize this risk, practitioners often perform allergy tests before treatment, especially when using certain types of fillers. It’s crucial for patients to disclose any known allergies or previous adverse reactions to their healthcare provider before undergoing filler treatments.

Vascular Occlusion and Necrosis: Vascular occlusion is a rare but serious complication that occurs when filler material is accidentally injected into or compresses a blood vessel, blocking blood flow. This can lead to tissue necrosis, or death of the surrounding tissue, due to lack of oxygen and nutrients. The risk is higher in areas with a rich blood supply, such as around the eyes and nose. Symptoms of vascular occlusion include immediate blanching of the skin, followed by pain, discoloration, and eventually tissue breakdown if left untreated. Necrosis can result in permanent scarring or disfigurement. Prompt recognition and treatment are crucial to prevent or minimize tissue damage. Treatment may involve dissolving the filler (if hyaluronic acid-based), administering vasodilators, and hyperbaric oxygen therapy. Prevention relies on the injector’s thorough understanding of facial anatomy and proper injection techniques.

Vision Abnormalities and Blindness: One of the most severe complications associated with soft tissue fillers is the potential for vision abnormalities and, in extreme cases, blindness. This rare but devastating complication occurs when filler material enters the blood vessels that supply the eye, blocking blood flow to the retina or optic nerve. Areas at highest risk for this complication include the glabella (between the eyebrows), nose, and forehead. Symptoms can include immediate vision loss, pain, or a headache. Even temporary vision changes during or immediately after injection should be treated as a medical emergency. Prevention is key and involves using proper injection techniques, understanding facial vascular anatomy, and avoiding high-risk areas. Once vision loss occurs, treatment options are limited and often unsuccessful, underscoring the importance of seeking treatment only from experienced, qualified practitioners.

Stroke: While extremely rare, stroke is a potential complication of soft tissue filler injections that can have severe, life-altering consequences. A stroke can occur if filler material enters the bloodstream and travels to the brain, blocking blood flow to a portion of the brain tissue. This can happen if filler is accidentally injected directly into an artery or if excessive pressure during injection forces filler into the vascular system. Symptoms of a stroke can include sudden weakness or numbness on one side of the body, difficulty speaking, severe headache, or loss of consciousness. The risk of stroke is higher when fillers are injected into certain high-risk areas of the face, particularly around the nose and between the eyebrows. To minimize this risk, practitioners must have a thorough understanding of facial anatomy and use proper injection techniques. Immediate medical attention is crucial if any symptoms of stroke occur during or after a filler procedure.

Frequently Asked Questions

How long do soft tissue fillers last?

The duration of soft tissue fillers typically ranges from 6 to 18 months, depending on the type of filler used and the area treated. Some fillers can last even longer, providing semi-permanent results.

Are soft tissue fillers safe?

Soft tissue fillers are generally considered safe when administered by a qualified, experienced professional. However, like any medical procedure, they carry some risk of side effects and complications, so it is crucial to choose a reputable provider.

Can soft tissue fillers replace a surgical facelift?

Soft tissue fillers can effectively address certain signs of aging and enhance facial contours, but they do not provide the same comprehensive results as a surgical facelift. They are best suited for individuals seeking non-surgical options for facial rejuvenation.

How much do soft tissue filler treatments cost?

The cost of soft tissue filler treatments varies based on the type of filler used, the amount required, and the provider's fees. Prices can range from a few hundred to several thousand dollars per session.

What is the difference between soft tissue fillers and Botox?

Soft tissue fillers add volume and smooth wrinkles by filling in areas of volume loss, while Botox relaxes muscles to reduce the appearance of dynamic wrinkles caused by facial expressions. Both can be used in combination for optimal results.

What should I do if I experience severe pain or vision changes after filler injections?

If you experience severe pain or any vision changes after filler injections, it is important to seek immediate medical attention. Contact your provider or go to an emergency room as these symptoms may indicate a serious complication.

Conclusion

Soft tissue fillers offer a versatile and effective solution for facial rejuvenation, providing immediate results with minimal downtime. They can restore lost volume, smooth out wrinkles, and enhance facial contours, making them a popular choice for those seeking non-surgical aesthetic improvements. However, it is essential to consult with a qualified, experienced provider to ensure safety and achieve the best possible outcomes. By understanding the benefits, risks, and proper maintenance of soft tissue fillers, patients can make informed decisions and enjoy the rejuvenating effects of these advanced cosmetic treatments.

Was this article helpful?

Yes
No

References:

Liao, Z. F., Cong, L. Y., Li, F. W., Wang, S. W., Liu, F. C., Wang, H. B., & Luo, S. K. (2024). The Research Trend of Soft Tissue Filler Injection from 2000 to 2022: A Bibliometric and Visualized Analysis.

https://journals.lww.com/prsgo/fulltext/2024/02000/the_research_trend_of_soft_tissue_filler_injection.7.aspx

Cassuto, D., Bellia, G., & Schiraldi, C. (2021). An Overview of Soft Tissue Fillers for Cosmetic Dermatology: From Filling to Regenerative Medicine.

https://www.dovepress.com/an-overview-of-soft-tissue-fillers-for-cosmetic-dermatology-from-filli-peer-reviewed-fulltext-article-CCID

Dr. Aurora Kalmanson

Always Consult a Medical Specialist

The information provided in this blog is for informational and educational purposes only and should not be interpreted as personalized medical advice. It's crucial to understand that while we are medical professionals, the insights and advice we provide are based on general research and studies. They are not tailored to individual health needs or conditions. Thus, it is essential to consult directly with a healthcare provider who can offer personalized medical advice relevant to your specific situation.