PRF Gel Filler: The Path to Lasting Beauty

Medically Reviewed
Medically Reviewed by Dr. Aurora Kalmanson on
Written by Fillers Editorial Team, plastic surgery specialists.

PRF Gel Filler is a groundbreaking advancement in aesthetic medicine, offering a natural alternative to synthetic fillers. Utilizing the body’s own platelet-rich fibrin, this treatment uses the power of growth factors, stem cells, and cytokines to rejuvenate the skin.

It effectively addresses concerns such as under-eye circles, fine lines, and volume loss, with minimal side effects and long-lasting results. PRF Gel Filler represents a significant leap forward in promoting skin health and youthful appearance, influencing the body’s innate healing mechanisms for cosmetic enhancement.

PRF Gel Filler Explained

PRF Gel Filler is a state-of-the-art regenerative therapy that taps into the body’s own healing resources to revitalize facial skin. It’s a sophisticated evolution from traditional treatments, offering a more natural approach to skin rejuvenation.

From PRP to PRF: The Evolution and Science

Platelet-Rich Fibrin Explained: Platelet-Rich Fibrin (PRF) is a second-generation platelet concentrate, rich in platelets, fibrin, and a small amount of white blood cells. Unlike its predecessor, Platelet-Rich Plasma (PRP), PRF is obtained by spinning the patient’s blood at a lower speed, avoiding the use of anticoagulants. This process results in a fibrin matrix that acts as a foundation, prolonging the release of growth factors and enhancing the healing and rejuvenation process. The natural fibrin network in PRF not only supports the structure of the injected area but also promotes angiogenesis and tissue regeneration, making it a superior choice for natural aesthetic improvements.

Advancements and Key Differences: The transition from PRP to PRF marks a significant advancement in regenerative aesthetics. PRF’s lower centrifugation speed allows for a richer concentration of fibrin, white blood cells, and stem cells, which are crucial for tissue regeneration. This key difference results in a more sustained release of growth factors, offering a longer-lasting effect compared to PRP. Additionally, the absence of anticoagulants in PRF means that the body’s natural healing process is not interrupted, leading to a more efficient and effective rejuvenation. The gel-like consistency of PRF also provides a natural volumizing effect, making it an excellent option for areas that require subtle enhancement, such as under-eye hollows and fine lines.

The PRF Gel Filler Procedure

The PRF Gel Filler procedure is a meticulous process that begins with careful preparation and follows through to precise application, ensuring optimal results and patient satisfaction.

Pre-Treatment Preparation

Hydration, Nutrition, and Medication Guidelines: Proper hydration and nutrition are essential in the days leading up to a PRF Gel Filler treatment. Patients are advised to drink plenty of water to ensure adequate blood volume and flow, which can facilitate the collection process and enhance the quality of the PRF. A balanced diet rich in vitamins and minerals, particularly those that support skin health and healing, such as vitamin C, zinc, and protein, is recommended. Additionally, patients should stick to specific medication guidelines provided by their practitioner, which may include pausing certain supplements and medications that could affect blood clotting or the healing process. By following these guidelines, patients can help maximize the effectiveness of their PRF treatment and support a smooth recovery.

Alcohol Restrictions and Dietary Considerations: In preparation for a PRF Gel Filler session, patients are typically advised to avoid alcohol consumption for a few days prior to the procedure. Alcohol can have a thinning effect on the blood and may increase the likelihood of bruising and swelling at the injection sites. Dietary considerations also play a role in pre-treatment preparation. Patients may be instructed to avoid certain foods that could potentially interfere with blood clotting or the body’s inflammatory response. Sticking to these dietary restrictions helps ensure that the body is in the best possible condition for the treatment, thereby enhancing the overall outcome and minimizing potential side effects.

Step-by-Step Treatment Process

Blood Sample Collection: The PRF Gel Filler treatment commences with the collection of a small blood sample from the patient. This step is performed with precision and care to ensure patient comfort and the integrity of the sample. The amount of blood drawn depends on the treatment area’s size and the volume of PRF needed. The process is similar to a routine blood test and is typically quick. The collected blood is then immediately processed to prevent clotting and degradation of the valuable components. This sample is the source material for the PRF and must be handled with meticulous attention to maintain its quality and potential for effective treatment.

Centrifugation and PRF Gel Creation: Once the blood sample is collected, it undergoes a specialized centrifugation process. The centrifuge is set to a low speed, which separates the blood into distinct layers without the use of anticoagulants. The top layer, rich in platelets, fibrin, and white blood cells, is the PRF used in the treatment. This layer is carefully extracted to avoid contamination with the other blood components. The PRF is then prepared into a gel-like substance, which will serve as the natural filler. This gel is rich in growth factors and cytokines, essential for stimulating the body’s regenerative processes and improving skin quality.

Controlled Cooling and Heating: The PRF gel’s creation involves a controlled cooling and heating process that is crucial for achieving the desired consistency and activating the biological components. The PRF is first cooled to enhance the concentration of the fibrin matrix, which provides a base for the growth factors and cells. It is then gently heated to create a malleable gel that can be easily injected into the treatment areas. This temperature modulation is carefully monitored to preserve the biological activity of the growth factors and ensure the gel’s stability and effectiveness.

Injection Techniques and Areas: The injection of PRF gel requires skill and precision. Practitioners use various techniques adapted to the specific treatment areas and desired outcomes. Common injection sites include under the eyes, cheeks, nasolabial folds, and other areas that may benefit from volume restoration or skin rejuvenation. The practitioner may use a combination of micro-needling and strategic placement to maximize the gel’s distribution and effectiveness. The goal is to achieve a natural-looking enhancement that harmonizes with the patient’s facial features and provides long-lasting results.

Recovery, Aftercare, and Maintenance

Post-treatment care is crucial for maximizing the benefits of PRF Gel Filler and ensuring a smooth recovery.

Post-Treatment Care Instructions

Managing Side Effects and Resuming Activities: After receiving PRF Gel Filler, patients may experience common side effects such as mild swelling, bruising, or redness at the injection sites. These are typically temporary and can be managed with simple measures like cold compresses and over-the-counter pain relievers if necessary. Most patients can resume their normal activities shortly after the procedure, but it’s important to avoid strenuous exercise and excessive heat exposure for a few days. The practitioner will provide detailed aftercare instructions adapted to the patient’s specific treatment areas and needs. Following these guidelines helps to minimize side effects and supports the healing process for optimal results.

Sun Exposure and Skin Care: Proper skin care and sun protection are vital after PRF Gel Filler treatments. Patients are advised to limit sun exposure and apply a broad-spectrum sunscreen with an appropriate SPF to protect the treated areas from UV damage. This is especially important in the days following the procedure, as the skin is more susceptible to sunburn and hyperpigmentation. Additionally, using gentle, non-irritating skin care products can help maintain the health and appearance of the skin. Hydrating serums and creams that support the skin’s barrier function are recommended to enhance the regenerative effects of the PRF treatment. By sticking to these skin care guidelines, patients can extend the benefits of their treatment and promote lasting skin health.

Frequently Asked Questions

How long does it take for PRF injections to work?

Initial improvements may be seen immediately due to the volumizing effect, with more significant natural rejuvenation and skin quality enhancements developing over several weeks to months.

What is the difference between PRP and PRF?

PRF is spun at a lower speed than PRP, resulting in a richer concentration of fibrin, white blood cells, and stem cells, which allows for a slower, sustained release of growth factors.

Are there any side effects to PRF filler treatments?

Common side effects include temporary bruising, swelling, and redness at the injection sites, which typically resolve within a few days.


PRF Gel Filler is a revolutionary treatment that offers a natural and effective way to rejuvenate the skin and address various cosmetic concerns. By utilizing the body's own healing mechanisms, it provides immediate volumization and long-term skin quality improvements with minimal side effects. Ideal for individuals seeking a less invasive and more biocompatible option, PRF Gel Filler stands out as a safe and sustainable choice in the realm of aesthetic medicine. With proper care and maintenance, the results can be long-lasting, providing patients with a refreshed and youthful appearance.

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Mahmoodabadi, R. A., Golafshan, H. A., Pezeshkian, F., Shahriarirad, R., & Namazi, M. R. (2023). Evaluation of the Effect of Platelet-Rich Fibrin Matrix in the Correction of Periorbital Wrinkles: An Experimental Clinical Trial.

Dashore, S., Chouhan, K., Nanda, S., & Sharma, A. (2021). Platelet-Rich Fibrin, Preparation and Use in Dermatology.,_preparation_and_use_in.7.aspx

Dr. Aurora Kalmanson

Always Consult a Medical Specialist

The information provided in this blog is for informational and educational purposes only and should not be interpreted as personalized medical advice. It's crucial to understand that while we are medical professionals, the insights and advice we provide are based on general research and studies. They are not tailored to individual health needs or conditions. Thus, it is essential to consult directly with a healthcare provider who can offer personalized medical advice relevant to your specific situation.