Natural Under Eye Filler

Medically Reviewed
Medically Reviewed by Dr. Aurora Kalmanson on
Written by Fillers Editorial Team, plastic surgery specialists.

Natural under eye fillers, particularly Platelet-Rich Fibrin Matrix (PRFM), offer a revolutionary approach to treating under eye hollows and rejuvenating the delicate eye area. PRFM, derived from the patient’s own blood, provides a safe and natural alternative to synthetic fillers, reducing the risk of allergic reactions and delivering long-lasting results.

This treatment not only addresses the cosmetic concerns of under eye hollows but also promotes natural healing and tissue regeneration for a refreshed and youthful appearance.

The PRFM Treatment Process

The PRFM treatment process is a meticulous and personalized approach, beginning with a thorough consultation to ensure the suitability of the candidate, followed by the precise preparation and injection of PRFM to rejuvenate the under eye area.

Consultation and Candidate Selection

Assessing Skin Quality and Under Eye Anatomy: The initial step in the PRFM treatment process involves a detailed evaluation of the skin’s quality and the anatomical structure of the under eye region. This assessment is crucial as it determines the specific needs of the patient and the potential effectiveness of the treatment. Factors such as skin thickness, elasticity, and the extent of volume loss are carefully examined. The presence of fine lines, wrinkles, and the overall skin tone are also considered. This comprehensive analysis ensures that the PRFM treatment is adapted to address the unique characteristics of each individual’s under eye area, optimizing the chances of a successful outcome.

Determining Suitability for PRFM Treatment: Determining a patient’s suitability for PRFM treatment is a critical aspect of the consultation process. Not all individuals experiencing under eye hollows are ideal candidates for PRFM. Factors such as the presence of severe eye bags, significant skin laxity, or underlying health conditions may affect eligibility. A thorough medical history is taken to identify any contraindications, and expectations are managed by discussing realistic outcomes. The goal is to ensure that PRFM is not only safe for the patient but also likely to provide the desired aesthetic results, enhancing the under eye area naturally and effectively.

PRFM Injection Technique

Preparation of PRFM from Patient’s Blood: The preparation of PRFM is a precise science that begins with the collection of a small amount of the patient’s blood. This sample is then subjected to a specialized centrifugation process, which separates the plasma and platelets from the other blood components. The resulting Platelet-Rich Fibrin Matrix is a concentrated source of growth factors and healing elements. This preparation is carefully handled to maintain the integrity of the PRFM, ensuring that when reintroduced to the patient’s under eye area, it will effectively stimulate the natural regenerative processes of the skin, leading to improved volume and texture.

Injection Sites and Depth: The technique for injecting PRFM into the under eye area is a delicate procedure that requires precision and expertise. The specific injection sites and the depth of injection are determined based on the individual’s anatomy and the extent of correction needed. Typically, injections are made along the orbital rim, where the hollows are most pronounced. The depth of injection is critical; too superficial can lead to visible irregularities, while too deep may reduce the effectiveness of the treatment. The aim is to deposit the PRFM in a plane where it can best support tissue regeneration and provide a smooth, natural enhancement to the under eye area.

Importance of Injector Experience and Skill: The success of PRFM under eye treatments hinges significantly on the skill and experience of the injector. Expertise in facial anatomy is essential to ensure the PRFM is placed accurately and at the correct depth, minimizing risks and maximizing results. Experienced injectors are adept at customizing injection techniques to the unique contours of each patient’s under eye area, which is vital for achieving a natural and symmetrical appearance. They are also trained to anticipate and manage any potential complications, ensuring patient safety and satisfaction. Choosing a qualified and skilled professional is very important for patients seeking the benefits of PRFM treatments.

Recovery and Aftercare

Common Side Effects and Their Management: Following a PRFM injection, patients may experience common side effects such as mild swelling, redness, or bruising at the injection sites. These are typically short-lived and can be managed with simple measures like cold compresses to reduce swelling and over-the-counter pain relievers for discomfort. It’s important for patients to follow their injector’s specific aftercare instructions, which may include avoiding strenuous activities and direct sun exposure for a certain period. Proper management of these side effects is crucial for a smooth recovery and optimal healing.

Avoiding Certain Activities and Products: Post-treatment care for PRFM injections involves avoiding certain activities and products that could worsen side effects or affect the results. Patients are advised to refrain from vigorous exercise, alcohol consumption, and blood-thinning medications for a period of time as these can increase the risk of bruising and swelling. Additionally, certain skincare products, particularly those containing retinoids or acids, should be avoided immediately after treatment to prevent irritation. Sticking to these guidelines helps ensure a comfortable recovery and contributes to the longevity of the treatment’s aesthetic benefits.

Potential Risks and Complications

Bruising and Swelling: Bruising and swelling are among the most common complications associated with PRFM injections. While typically mild and temporary, these side effects can vary in intensity and duration depending on the individual’s response to the treatment. To minimize the likelihood of bruising, patients are often advised to avoid blood-thinning supplements and medications before the procedure. Swelling can be managed with cold compresses and elevation, and both side effects generally resolve within a few days to a week.

Lumps and Unevenness: Lumps and unevenness may occur if PRFM is not injected evenly or if it accumulates in certain areas. Skilled injectors use meticulous techniques to ensure smooth distribution of PRFM, but should irregularities arise, gentle massage and follow-up treatments can help to settle these issues. It’s important for patients to monitor their under eye area and report any persistent lumps or asymmetry to their injector for prompt assessment and intervention.

Tyndall Effect (Bluish Discoloration): The Tyndall effect is a potential complication of under eye filler treatments, characterized by a bluish discoloration of the skin. This phenomenon occurs when the filler is injected too superficially, causing light to scatter in the dermis and create a blue hue. While not harmful, it can be aesthetically displeasing. The risk of the Tyndall effect can be minimized by proper injection technique and the use of appropriate filler products. If it does occur, the discoloration can be corrected by dissolving the filler with hyaluronidase, allowing for re-treatment or alternative approaches to under eye rejuvenation.

Vascular Occlusion and Vision Loss (Rare): Vascular occlusion is an extremely rare but serious complication that can occur if filler is inadvertently injected into a blood vessel. This can lead to impaired blood flow and, in the worst cases, vision loss. The risk is minimized by choosing an experienced injector who is familiar with facial vascular anatomy and uses safe injection techniques. Immediate action is required if vascular occlusion is suspected, including dissolving the filler with hyaluronidase and seeking urgent medical attention to manage the occlusion and prevent long-term damage.

Frequently Asked Questions

How long does PRFM last compared to traditional fillers?

PRFM results can last up to a year or longer, which is typically more enduring than traditional hyaluronic acid fillers due to the natural collagen production it stimulates.

Is there any downtime after a PRFM treatment?

Downtime after PRFM is minimal, with most patients able to resume normal activities within a day, although some may experience mild swelling or bruising.

Can PRFM be used for other areas of the face besides the under eyes?

Yes, PRFM can be used in other facial areas requiring volume enhancement or rejuvenation, such as cheeks, nasolabial folds, and marionette lines.

How many PRFM treatments are typically needed for optimal results?

Most patients achieve optimal results with one PRFM treatment, but some may benefit from a follow-up session for touch-ups or further volume enhancement.

Are there any long-term side effects associated with PRFM?

PRFM is generally considered safe with no significant long-term side effects, as it uses the patient's own blood, reducing the risk of allergic reactions or rejection.

Can PRFM be combined with other cosmetic treatments?

Yes, PRFM can be effectively combined with other treatments such as Botox, laser therapy, and microneedling for comprehensive facial rejuvenation.

How much does a PRFM treatment for under eye hollows typically cost?

The cost of PRFM treatment varies but generally ranges from $1,000 to $2,500, depending on the provider and the extent of treatment needed.

How does the longevity of PRFM compare to other natural fillers like fat transfer?

PRFM typically lasts up to a year or more, which may be shorter than fat transfer results; however, PRFM offers a less invasive approach with easier recovery.

How soon after a PRFM treatment can I wear makeup?

Patients can usually apply makeup 24 to 48 hours after PRFM treatment, but it's best to confirm with the provider.

Can PRFM help with dark circles caused by pigmentation?

PRFM may not directly address pigmentation issues, but it can improve overall skin quality and should be combined with other treatments targeting pigmentation.


In conclusion, PRFM stands as a promising natural alternative to traditional under eye fillers, offering a safe and long-lasting solution to under eye hollows. With minimal downtime and suitability for all skin types, PRFM not only enhances volume but also promotes skin health through collagen stimulation. When selecting a treatment, it's essential to consider individual needs and consult with an experienced provider to achieve the best results. Combining PRFM with other cosmetic procedures can further optimize outcomes, ensuring a refreshed and youthful appearance.

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Hu, S., Bassiri-Tehrani, M., & Abraham, M. T. (2021). The Effect of Platelet-Rich Fibrin Matrix on Skin Rejuvenation: A Split-Face Comparison.

Mahmoodabadi, R. A., Golafshan, H. A., Pezeshkian, F., Shahriarirad, R., & Namazi, M. R. (2023). Evaluation of the Effect of Platelet-Rich Fibrin Matrix in the Correction of Periorbital Wrinkles: An Experimental Clinical Trial.

Dr. Aurora Kalmanson

Always Consult a Medical Specialist

The information provided in this blog is for informational and educational purposes only and should not be interpreted as personalized medical advice. It's crucial to understand that while we are medical professionals, the insights and advice we provide are based on general research and studies. They are not tailored to individual health needs or conditions. Thus, it is essential to consult directly with a healthcare provider who can offer personalized medical advice relevant to your specific situation.