Lip Filler Infection Signs: Early Symptoms to Watch For

Medically Reviewed
Medically Reviewed by Dr. Aurora Kalmanson on
Written by Fillers Editorial Team, plastic surgery specialists.

Lip filler procedures are generally safe, but like any cosmetic treatment, they carry the risk of infection. Recognizing the signs of an infection early is crucial for effective treatment and can prevent further complications.

Key indicators of a lip filler infection include persistent redness, swelling, pain, and warmth at the injection site, often accompanied by pus or discharge. If you experience these symptoms, especially within the first week post-procedure, seek medical attention promptly. Understanding the causes, symptoms, and treatment options is essential for anyone considering lip fillers.

Signs and Symptoms of Lip Filler Infections

Recognizing the signs and symptoms of lip filler infections is crucial for timely intervention and treatment, ensuring the best possible outcomes for patients.

Early Signs (Within the First Week)

Redness and Swelling: Redness and swelling at the injection site are common immediate reactions to lip filler treatments. However, if these symptoms persist beyond the typical healing period or intensify, it may indicate an infection. An infection-related redness often extends beyond the immediate area of the injection site and may be accompanied by increased swelling that does not subside with standard aftercare measures.

Pain and Tenderness: While some discomfort is expected after a lip filler procedure, persistent or escalating pain and tenderness are concerning. These symptoms, particularly if localized to one area or if they develop after the initial post-procedure period, can be indicative of an infection. Pain that worsens over time or does not respond to over-the-counter pain relief should be evaluated by a healthcare professional.

Warmth at the Injection Site: A warm sensation at the injection site can be a normal part of the inflammatory response following lip filler injections. However, if the warmth is pronounced, localized, and persists alongside other symptoms such as redness and swelling, it may be a sign of an underlying infection. The warmth is a result of increased blood flow as the body attempts to fight off the infection, and medical assessment is necessary to determine the appropriate course of action.

Itching and Redness at Specific Points: Itching and redness localized to specific points, such as the oral commissure, can be early indicators of an infection or an allergic reaction to the lip filler. While mild itching can be a normal part of the healing process, persistent or intense itching accompanied by redness and discomfort should not be ignored. These symptoms can also signal the reactivation of herpes simplex virus in patients with a history of cold sores, needing prompt medical evaluation and treatment.

Later Signs (After the First Week)

Persistent Swelling and Inflammation: Swelling that remains or worsens after the initial post-injection period may be a sign of an ongoing inflammatory response to an infection. Inflammation that persists beyond the expected recovery time, especially if it’s accompanied by other symptoms like redness or heat, should be assessed by a healthcare provider. Chronic inflammation can lead to more serious complications and may require intervention with medications or other treatments.

Abscess Formation: An abscess is a collection of pus that has built up within the tissue due to an infection. It presents as a painful, swollen area that may feel warm and appear red. Abscesses can form as a result of a bacterial infection at the filler site and require immediate medical attention. Treatment typically involves drainage and antibiotics to clear the infection and prevent further complications.

Nodules or Lumps: Nodules or lumps that develop after the first week post-treatment can be a cause for concern. These may be indicative of a granulomatous reaction, where the body perceives the filler as a foreign substance and creates granulomas, or they may be due to an infection. Such nodules can be tender or painless but should be evaluated by a medical professional to determine the appropriate course of action.

Pus or Discharge: The presence of pus or discharge from the injection site is a clear sign of infection. This discharge may be white, yellow, or green and is often accompanied by other signs of infection such as redness, swelling, and pain. Any drainage from the lip filler area should be promptly assessed by a healthcare provider, as it may require antibiotic treatment or other interventions to sort out the infection.

Fever and Systemic Symptoms: Fever and systemic symptoms such as body aches, chills, and fatigue following a lip filler procedure may indicate that an infection has spread beyond the local injection site. These symptoms suggest that the body is fighting a systemic infection, which can be a serious condition requiring immediate medical attention. In such cases, healthcare providers will typically conduct a thorough evaluation and may prescribe systemic antibiotics or other treatments to manage the infection.

Atypical Presentations

Delayed Onset Infections: Delayed onset infections are subtle and can occur weeks to months after the initial lip filler treatment. They are often caused by biofilms, which are complex communities of bacteria that stick to surfaces and are resistant to antibiotics. These infections can present with subtle symptoms that persist over time, such as slight swelling or firmness at the injection site. Due to their resistance to standard treatments, biofilms require a specialized approach for effective management.

Recurrent Infections: Recurrent infections at the site of lip filler injections can be particularly challenging. These may occur due to incomplete resolution of the initial infection or due to a predisposition of the treated area to foster bacteria. Patients experiencing repeated infections may need a comprehensive evaluation to identify underlying causes and to develop an adapted treatment plan that may include long-term antibiotics or removal of the filler material.

Treatment Options for Lip Filler Infections

Effective treatment of lip filler infections is essential to resolve the infection, alleviate symptoms, and prevent further complications.

Immediate Medical Attention and Antibiotics

Oral Antibiotics (e.g., Cephalexin, Clindamycin): Oral antibiotics are often the first line of defense against lip filler infections. Medications such as cephalexin and clindamycin are commonly prescribed to combat the bacteria responsible for the infection. The choice of antibiotic will depend on the type of bacteria identified, the severity of the infection, and the patient’s medical history, including any known drug allergies. It is important for patients to complete the full course of antibiotics as prescribed to ensure the infection is fully eradicated.

IV Antibiotics for Severe Cases: In severe cases of lip filler infection, where there is evidence of rapid progression, systemic involvement, or when the patient is immunocompromised, intravenous (IV) antibiotics may be necessary. This method delivers a higher concentration of antibiotics directly into the bloodstream, providing a more immediate and potent response to the infection. Hospitalization may be required for close monitoring and to administer the IV antibiotics as per the treatment regimen.

Antibiotic Regimens and Duration: The regimen and duration of antibiotic treatment for lip filler infections are determined based on the severity of the infection and the type of microorganism identified. Typically, a course of antibiotics may last from 7 to 14 days; however, more persistent infections may require extended treatment. It is crucial for patients to stick to the prescribed regimen, taking the medication at the correct intervals and for the full duration, even if symptoms improve, to prevent the development of antibiotic-resistant bacteria and ensure complete eradication of the infection.

Drainage and Removal of Infected Material

Drainage and removal of infected material are often necessary steps in treating lip filler infections. This procedure involves making a small incision to drain pus and infected fluid, which can provide immediate relief of pressure and pain. In some cases, the removal of the infected filler material may also be required to eliminate the source of the infection. This process should be performed by a qualified healthcare professional under sterile conditions to prevent further contamination. Culturing the drained material can guide the selection of appropriate antibiotics to treat the underlying infection.

Hyaluronidase Injections to Dissolve Fillers

Indications and Timing: Hyaluronidase injections are indicated when there is a need to dissolve hyaluronic acid-based fillers, either due to an infection or to correct overfilling or misplacement of the filler. The timing of hyaluronidase administration is critical; it is often used after initial attempts at treating the infection with antibiotics. In cases of vascular occlusion or severe infection, hyaluronidase may be used more urgently to prevent tissue damage.

Allergy Testing and Precautions: Before administering hyaluronidase, allergy testing may be performed to ensure the patient does not have a hypersensitivity to the enzyme, which could lead to an allergic reaction. Precautions include reviewing the patient’s medical history for previous reactions and observing for any adverse effects post-injection. The use of hyaluronidase should be carefully considered and monitored by a healthcare professional.

Supportive Care and Wound Management

Supportive care and wound management are integral parts of treating lip filler infections. This includes measures to reduce swelling, such as applying cold compresses, and pain management with appropriate analgesics. Wound care may involve regular cleaning with saline or antiseptic solutions and the application of topical antibiotics if indicated. In some cases, protective dressings may be used to cover the area and promote healing. Patient education on how to care for the wound at home is essential to prevent reinfection and ensure proper recovery.

Management of Atypical Infections

Antifungal Medications: Atypical infections such as those caused by fungi are rare in the context of lip fillers but require specific management when they occur. Antifungal medications are the cornerstone of treatment for fungal infections, which may present with persistent swelling, discoloration, or unusual discharge at the injection site. The choice of antifungal will depend on the type of fungus identified and may include topical or systemic agents. Treatment duration can be extensive, often several weeks, to ensure complete resolution of the infection.

Antiviral Medications: In cases where a viral infection is suspected, such as reactivation of the herpes simplex virus, antiviral medications are prescribed. These medications help to reduce the severity and duration of symptoms like blisters and sores. Early intervention with antivirals is crucial, especially if symptoms are recognized shortly after the lip filler procedure. The timely administration of these drugs can prevent the spread of the virus and mitigate its impact on the healing process.

Frequently Asked Questions

How common are lip filler infections?

Lip filler infections are relatively rare, occurring in a small percentage of cases, with some data suggesting rates between 1 in 500 to 1 in 2500 treatments.

Can lip filler infections spread to other parts of the face?

Yes, if not treated promptly, lip filler infections can spread to other parts of the face and potentially lead to more serious complications.

How long does it take for lip filler infection symptoms to appear?

Symptoms of a lip filler infection can appear within 24 hours to two weeks post-procedure, with delayed infections potentially developing weeks to months later.

Can lip filler infections be treated at home?

While minor symptoms may be managed at home, it is crucial to seek medical advice for any suspected infection. Home remedies should not replace professional medical treatment.

How can I tell if my lip filler swelling is normal or a sign of infection?

Normal swelling from lip fillers typically subsides within a few days, whereas swelling from an infection may persist, worsen, and be accompanied by other signs like redness, pain, or pus.

What should I do if I suspect I have a lip filler infection?

If you suspect an infection, contact your healthcare provider immediately for an assessment and appropriate treatment.

Can I get lip fillers again after having an infection?

It is possible to get lip fillers again after an infection has been fully resolved, but it is essential to discuss this with your healthcare provider to assess the risks.

Are there any long-term consequences of lip filler infections?

If treated promptly, most lip filler infections do not lead to long-term consequences. However, severe or untreated infections can result in scarring or permanent tissue damage.

Can poor injection technique increase the risk of infections?

Yes, poor injection technique can increase the risk of infections by introducing bacteria into deeper tissue layers or causing unnecessary trauma to the skin.

Is it necessary to remove the filler if an infection occurs?

In some cases, especially if the infection is severe or not responding to antibiotics, it may be necessary to remove the filler material to effectively treat the infection.

Can lip filler infections lead to scarring or permanent damage?

Untreated or severe lip filler infections can lead to scarring or permanent damage, emphasizing the importance of early detection and treatment.


Lip filler infections, while uncommon, require prompt recognition and treatment to prevent complications. Understanding the signs, causes, and appropriate management strategies is essential for anyone considering or having undergone lip filler procedures. By adhering to best practices for prevention, such as selecting a qualified provider and following proper aftercare, the risks can be minimized. Should an infection occur, early medical intervention is key to ensuring a safe and satisfactory outcome.

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Haneke E. (2015). Managing Complications of Fillers: Rare and Not-So-Rare.

Wagner, R. D., Fakhro, A., Cox, J. A., & Izaddoost, S. A. (2016). Etiology, Prevention, and Management of Infectious Complications of Dermal Fillers.

Dr. Aurora Kalmanson

Always Consult a Medical Specialist

The information provided in this blog is for informational and educational purposes only and should not be interpreted as personalized medical advice. It's crucial to understand that while we are medical professionals, the insights and advice we provide are based on general research and studies. They are not tailored to individual health needs or conditions. Thus, it is essential to consult directly with a healthcare provider who can offer personalized medical advice relevant to your specific situation.