How to Dissolve Filler Without Hyaluronidase – A Safe Alternative

Medically Reviewed
Medically Reviewed by Dr. Aurora Kalmanson on
Written by Fillers Editorial Team, plastic surgery specialists.

Discovering options for dissolving unwanted dermal fillers provides an alternative path for those seeking to reverse or adjust their aesthetic treatments. Though hyaluronidase has been the go-to for dissolving hyaluronic acid-based fillers, concerns about allergic reactions and the desire for non-animal-based options have paved the way for novel solutions.

Enter Topilase, a topical, non-injectable therapy that caters to these concerns while offering a safe and effective means to reduce unwanted filler. Combining a unique mix of enzymes with natural, soothing ingredients, Topilase presents itself as a game changer in aesthetic corrections.

Topilase: A Safer Alternative to Hyaluronidase

The search for a non-invasive, hypoallergenic option led to the development of Topilase, a groundbreaking product that promises a less aggressive approach to manage complications of hyaluronic acid fillers while maintaining safety and efficiency.

What is Topilase?

Composition and Ingredients: Topilase stands out with its synergistic blend of enzymes—protease, lipase, and hyaluronidase—expertly formulated to penetrate the skin and break down hyaluronic acid chains. Its distinct composition is accentuated by the infusion of natural elements such as aloe vera, lavender, helichrysum, cistus, and myrrh. These ingredients are celebrated for their calming, purifying, revitalizing, and regenerative properties, which complement the enzymatic action in reducing unsightly surface volumes.

This topical solution, free of animal-derived constituents, significantly diminishes the risk of allergic reactions. It is also focused on preventing the skin laxity and dehydration occasionally observed with injectable hyaluronidase. Patients typically undergo a series of three treatments spaced a week apart, witnessing gradual yet noticeable improvement in the treated areas.

How Topilase Works on Dissolving Fillers: Topilase operates by targeting the same substrate as injectable hyaluronidase—hyaluronic acid within fillers—but does so via a different delivery system. This topical cream penetrates the epidermis to reach the dermal filler material. Once in contact, its enzymatic components, including hyaluronidase, initiate the breakdown of hyaluronic acid chains. As a layer-based solution, Topilase is applied across the treatment area, thus providing a uniform outcome. Compared to injections, the topical approach offers a less invasive experience, attracting individuals hesitant about needles or seeking a gentler method of filler reversal.

Benefits of Using Topilase Over Hyaluronidase

Non-Animal Origin: Topilase’s appeal is largely due to its non-animal derived enzymes, distinguishing it from traditional animal-based hyaluronidase products. As society becomes more conscientious about the use of animal products, Topilase taps into a segment that values cruelty-free alternatives. Beyond aligning with ethical standards, its formulation mitigates moral and dietary conflicts, making it a thoughtful choice for the modern, ethical consumer.

Reduced Risk of Allergic Reactions: Allergic reactions are a concern with any medical treatment, particularly when animal-derived ingredients are involved. By employing a non-animal enzymatic complex, Topilase minimizes the likelihood of typical allergic responses triggered by animal proteins. This safety profile broadens the spectrum of individuals who can undergo filler reversal treatments, answering especially to those with known sensitivities or previous adverse reactions. As a precaution against uncommon hypersensitivity occurrences, clinicians might still opt for a patch test, despite the reduced risk.

Soothing and Repairing Effects of Natural Ingredients: Topilase not only reverses undesired cosmetic filler but does so while providing ancillary benefits due to its natural ingredients. Known for their reparative properties, substances like aloe vera and lavender oil impart calming effects on the skin. Additionally, helichrysum and myrrh, revered for their healing virtues in skincare, enhance the product’s profile. These soothing constituents work in tandem with the dissolving agents to not just erase mistakes but potentially improve the skin’s overall wellbeing—a dual-action that’s difficult to achieve with conventional dissolvers.

Effectiveness of Topilase in Reducing Unsightly Surface Volumes

Topilase’s effectiveness is evidenced in its capability to mitigate the undesirable volume caused by overfilling or migration of dermal fillers. The product focuses on superficial volumes, where precision and a delicate approach are very important. Given its comprehensive enzymatic makeup, Topilase orchestrates a gradual downsizing of the extraneous volume, allowing for a controlled and measured process. This can prevent the overly abrupt changes seen with stronger injectables, offering patients and practitioners latitude to more finely tune aesthetic outcomes. Such nuanced management can be particularly favorable for minor corrections and fosters confidence among patients regarding the reversibility of their aesthetic procedures.

The Topilase Treatment Process

The journey to rectify filler mishaps with Topilase involves a personalized approach, where individual factors dictate the specifics of the treatment plan, including the number of sessions.

Factors Affecting the Number of Sessions Required

Desired Result: Achieving the optimal outcome with Topilase is not a matter of a single universal protocol; rather, it hinges on each individual’s desired result. Some clients may seek subtle refinements—a minor reduction in filler volume—requiring fewer sessions, while significant adjustments may require a series to reach the intended correction. It’s this adjustable aspect of Topilase that allows practitioners to architect an adapted treatment regimen, carefully climbing up towards the patient’s aesthetic goal.

The treatment’s customizability offers a reassuring layer of control, as clients can pace their journey towards the desired endpoint. The clinician evaluates progress session by session, fostering an environment where changes are collaborative and reflective of the client’s evolving satisfaction.

Type of Hyaluronic Acid Filler Injected: Different hyaluronic acid fillers boast different properties, such as cross-linking density and particle size, which influence how readily they respond to Topilase. Heavily cross-linked fillers, designed for longevity and structure, may surrender their volume more gradually than less stable counterparts.

The composition and formulation of the original filler affect how Topilase’s enzymatic solution interacts with it. As a result, certain fillers may show immediate volume reduction, while others, with a more robust structure, could lead to a more drawn-out dissolution process across additional sessions.

Time Since Filler Injection: The interval between the original filler placement and the initiation of Topilase treatment plays an instrumental role. Newly injected fillers are often more responsive to dissolution, as they have yet to fully integrate within the skin’s fabric. In contrast, older fillers that have settled might require a longer duration of Topilase applications to weaken the established hyaluronic acid network.

Such temporal considerations are critical when planning the treatment schedule—recognizing that fillers become harmonized with the surrounding tissues over time, potentially influencing the enzymatic breakdown efficiency.

Injection Plane: The depth at which the filler has been injected profoundly affects the action of Topilase. Superficial placements, closer to the surface, make fillers more accessible to the topical enzyme solution, potentially allowing for a swifter response. On the other hand, deeper injections—situated further from the surface—might curb the topical enzyme’s reach, requiring a more patient approach involving additional sessions to achieve equivalent results.

Grasping the nuances of the injection plane assures that expectations are finely tuned to the possibility of filler dissolution, with a clear understanding that the placement dictates the path and pace of correction.

Recommended Treatment Schedule

Average Number of Sessions: While each case is unique, the average number of Topilase sessions typically falls around three. This figure provides a general framework, accommodating a spectrum of circumstances from moderate adjustment to more significant filler reduction. Each session contributes progressively towards the diminishing of unwanted filler, with the extent of change after a single application influencing subsequent treatments.

The balanced approach of Topilase ensures that the process isn’t rushed, allowing for careful assessment and adjustment. The clinician can calibrate the treatment intensity according to the patient’s evolving results, making sensitivity and personalization the cornerstones of this corrective procedure.

Spacing Between Sessions: Strategic spacing between Topilase sessions is essential for optimal results. It is advised to maintain approximately one week apart to allow the skin and underlying tissues to respond to the treatment and commence the degradation of the filler. This interval respects the natural cycles of skin turnover and healing, facilitating a safe and controlled approach to filler dissolution.

This time frame provides an opportunity to evaluate the efficacy of the initial session, enabling clinicians to adapt subsequent applications in response to the patient’s progress. The dynamic nature of this spacing endows the treatment process with the flexibility necessary to account for individual variability in response to Topilase.

Frequently Asked Questions

Is it safe to dissolve fillers without hyaluronidase?

Yes, it is safe when using an approved product like Topilase that is specifically designed to dissolve fillers without hyaluronidase.

How long does it take for Topilase to dissolve fillers?

Topilase typically begins to dissolve fillers within a few hours of application, with full results seen after a series of treatments, usually spaced a week apart.

Can Topilase be used on all types of fillers?

Topilase is formulated for hyaluronic acid-based fillers. Its suitability for other types of fillers should be discussed with a healthcare professional.

Are there any side effects associated with Topilase?

The side effects of Topilase can include bruising, tenderness, swelling, and redness, which are typically mild and temporary.

How soon can I get new fillers after using Topilase?

It is recommended to wait at least two weeks after the last Topilase treatment to allow the skin to recover before getting new fillers.

Is Topilase suitable for pregnant or breastfeeding women?

Topilase has not been tested for safety in pregnant or breastfeeding women, and its use is generally not recommended in these cases.

How much does a Topilase treatment cost compared to hyaluronidase?

The cost can vary, but Topilase may be comparable to or slightly higher in price than hyaluronidase treatments depending on the clinic and location.


Topilase emerges as a cutting-edge alternative to hyaluronidase in the world of filler dissolution, with its non-animal origin, reduced allergic risk, and potential for soothing effects. Considering the holistic treatment process, Topilase accommodates various contributing factors by offering a flexible schedule to suit individual patient needs. Acknowledging the multiple reasons for seeking filler reversal, from aesthetic fine-tuning to medical emergencies, Topilase demonstrates efficacy and safety. The aftercare period also plays an integral role, with appropriate measures facilitating recovery. A well-informed patient can navigate the use of Topilase effectively, with careful obedience to suggested guidelines and professional advice.

Was this article helpful?



Dr. Aurora Kalmanson

Always Consult a Medical Specialist

The information provided in this blog is for informational and educational purposes only and should not be interpreted as personalized medical advice. It's crucial to understand that while we are medical professionals, the insights and advice we provide are based on general research and studies. They are not tailored to individual health needs or conditions. Thus, it is essential to consult directly with a healthcare provider who can offer personalized medical advice relevant to your specific situation.