How Long After Dissolving Filler Can You Get More?

Medically Reviewed
Medically Reviewed by Dr. Aurora Kalmanson on
Written by Fillers Editorial Team, plastic surgery specialists.

After dissolving dermal filler with hyaluronidase, it’s generally recommended to wait at least 4-6 weeks before getting more filler. This waiting period allows for any swelling or bruising to subside, the body to heal properly, and for the natural lip shape and volume to be reassessed.

This ensures a better outcome for the next filler treatment, helping to avoid over-correction and asymmetry. It’s important to note that the exact timing can vary based on individual healing processes and the specifics of the initial filler and dissolution.

Understanding Filler Dissolution and Timing for Refill

Dermal filler dissolution is a nuanced process that requires careful consideration of timing and technique. The decision to refill post-dissolution should be made with an understanding of the body’s healing response and the effects of the dissolving agent.

The Role of Hyaluronidase in Filler Dissolution

Immediate Effects and Duration of Action: Hyaluronidase, an injectable enzyme, begins to break down hyaluronic acid fillers immediately upon injection. Despite its brief half-life of approximately two minutes, its action persists, with the most noticeable reduction in filler volume occurring within 48 hours. Patients may initially experience swelling, which can obscure the enzyme’s effects, but this typically resolves to reveal the diminished filler presence.

The Body’s Response to Hyaluronidase: Following the administration of hyaluronidase, the body initiates a healing response that includes swelling and, occasionally, bruising. This response is a natural part of the tissue’s recovery process. As the swelling subsides, usually within a few days, the true extent of the filler dissolution becomes apparent. It’s crucial to allow sufficient time for the body to return to its baseline state before considering additional treatments.

The Importance of Precision in Dissolving Filler: Precision in the application of hyaluronidase is critical to achieving the desired outcome. The enzyme should be administered carefully to target only the unwanted filler, preserving the surrounding tissue and maintaining the overall facial structure. This precision helps to avoid over-dissolution and ensures that any subsequent filler treatments can be performed accurately.

The Importance of Choosing an Experienced Practitioner: Selecting a practitioner experienced in using hyaluronidase is very important. An expert will have a deep understanding of the enzyme’s behavior, appropriate dosing, and injection techniques, which are essential for minimizing risks and achieving optimal results. Their expertise also allows for a more accurate assessment of when it is safe to proceed with additional filler treatments.

Factors Influencing the Waiting Period Before Refill

Swelling and Healing Post-Dissolution: The post-dissolution phase is characterized by an inflammatory response that includes swelling and sometimes bruising. This response is the body’s natural mechanism for healing, and the extent of swelling can vary from person to person. It’s essential to allow the body to complete this phase, which can take anywhere from a few days to a couple of weeks, before considering additional filler. During this time, the treated area should return to its natural state, free from the influence of both the filler and the swelling it caused.

Assessing Natural Lip Shape and Volume: After the swelling has subsided, a clear assessment of the natural lip shape and volume is possible. This step is crucial as it provides a baseline for any future filler treatments. Understanding the natural contours and fullness of the lips ensures that any additional filler is used to enhance rather than overshadow the inherent features, leading to more harmonious and satisfying results.

Amount and Type of Filler Used: The quantity and type of filler initially injected play a significant role in determining the waiting period before a refill. Different fillers have varying degrees of cross-linking and density, which can affect how quickly they are broken down by hyaluronidase and how they integrate with the tissue. Fillers that are more robust or were injected in larger volumes may require a longer waiting period to ensure they have been adequately dissolved and the tissues have returned to baseline.

Techniques and Tools: Needles, Cannulas, and Ultrasound: The techniques and tools used during both the filler injection and dissolution processes can influence the waiting period before a refill. Precision in targeting the filler for dissolution is enhanced with the use of ultrasound guidance, while the choice between needles and cannulas can affect the distribution and breakdown of the product. These factors, combined with the skill of the practitioner, determine how quickly and effectively the filler is dissolved and, consequently, how soon a refill can be safely administered.

Recommended Waiting Periods Post-Dissolution

General Guidelines for Refilling: The general consensus among medical professionals is to wait at least two weeks after dissolving fillers before considering a refill. This period allows for the complete action of hyaluronidase, the resolution of any inflammatory response, and the return of the tissues to their natural state. Sticking to this waiting period is not only a precautionary measure but also a necessary step to ensure that the lips are in optimal condition for the next treatment, allowing for precise assessment and injection of the new filler.

Reasons for the Waiting Period: The waiting period after dissolving fillers is crucial for several reasons. It allows time for any swelling and bruising to resolve, ensuring that the lips have returned to their natural state before additional filler is added. This period also provides an opportunity to observe the natural lip shape and volume, which is essential for planning the next steps in treatment. Moreover, waiting helps prevent over-correction and asymmetry, as it is easier to gauge the correct amount of filler needed when the lips are not distorted by swelling or remnants of previous filler.

Frequently Asked Questions

How long does it take for hyaluronidase to fully dissolve filler?

Hyaluronidase typically begins to break down filler immediately, with most of the action completed within 24 to 48 hours.

Can I get new filler immediately after dissolving the old one?

It is not recommended to get new filler immediately; waiting at least 4-6 weeks allows for proper healing and assessment of the natural lip shape.

What should I expect during the waiting period after dissolving filler?

During the waiting period, expect some swelling and bruising, which will subside to reveal the natural contours of the treated area.

How does the type of filler affect the dissolving process?

Different fillers have varying degrees of cross-linking, which can affect how quickly and completely they are dissolved by hyaluronidase.

Is it possible to only dissolve a portion of the filler and leave the rest?

Yes, it is possible to target and dissolve only a portion of the filler, but it requires precision and expertise from the practitioner.

How long should I wait after dissolving filler to get more?

It's generally recommended to wait at least 4-6 weeks after dissolving filler before considering a refill.

How can I ensure the best results when refilling after dissolving filler?

To ensure the best results, wait until swelling subsides, choose an experienced practitioner, and have a clear plan for the desired outcome.


In conclusion, while dissolving and refilling dermal fillers can be an effective way to adjust or correct aesthetic treatments, it is a process that requires careful consideration, expert execution, and patience. Understanding the timeline, managing expectations, and being aware of the potential risks are key to achieving satisfactory outcomes. Whether embracing natural features or seeking further enhancement, the decision to dissolve and refill should always be made in consultation with a qualified and experienced practitioner.

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King, M., Convery, C., & Davies, E. (2018). This month's guideline: The Use of Hyaluronidase in Aesthetic Practice (v2.4).

Dr. Aurora Kalmanson

Always Consult a Medical Specialist

The information provided in this blog is for informational and educational purposes only and should not be interpreted as personalized medical advice. It's crucial to understand that while we are medical professionals, the insights and advice we provide are based on general research and studies. They are not tailored to individual health needs or conditions. Thus, it is essential to consult directly with a healthcare provider who can offer personalized medical advice relevant to your specific situation.