Biostimulatory Fillers – Great Solution for Youthful Skin

Medically Reviewed
Medically Reviewed by Dr. Aurora Kalmanson on
Written by Fillers Editorial Team, plastic surgery specialists.

Biostimulatory fillers are a cutting-edge cosmetic treatment designed to not just fill in lines and restore lost volume, but to also stimulate the body’s own collagen production for more natural and long-lasting results. Unlike traditional fillers, these injectables work beneath the skin’s surface to rejuvenate from within, addressing deeper signs of aging and improving overall skin quality.

Ideal for those experiencing significant volume loss or skin laxity, biostimulatory fillers offer a promising solution for sustained youthfulness without frequent retreatments.

Types of Biostimulatory Fillers

Biostimulatory fillers encompass a variety of substances, each with unique properties and benefits. These fillers are chosen based on individual patient needs and the specific areas of concern they address.

Calcium Hydroxylapatite (CaHA)

Brand Names (e.g., Radiesse): Among the biostimulatory fillers, Radiesse stands out as a prominent brand name associated with calcium hydroxylapatite (CaHA). This filler is known for its ability to immediately correct volume loss while simultaneously stimulating natural collagen production. Radiesse’s microspheres form a scaffold that supports the skin’s structure, offering both immediate and progressive benefits. Its versatility and effectiveness have made it a popular choice for patients and practitioners alike.

Indications and Treatment Areas: Radiesse is indicated for a range of aesthetic concerns, from smoothing moderate to severe facial wrinkles and folds to restoring volume in areas of the face such as the cheeks and jawline. It is also FDA-approved for correcting volume loss in the back of the hands. The biostimulatory action of Radiesse makes it an excellent option for those seeking a dual benefit of immediate correction and long-term improvement.

Poly-L-Lactic Acid (PLLA)

Brand Names (e.g., Sculptra): Sculptra is a well-known brand within the poly-L-lactic acid (PLLA) category of biostimulatory fillers. Unlike immediate fillers, Sculptra works gradually, stimulating the body to produce collagen over time. This results in a natural and subtle volumization that can last up to two years or more. Sculptra’s unique formulation and long-lasting effects have made it a favored choice for comprehensive facial rejuvenation.

Gradual Collagen Stimulation: Poly-L-lactic acid (PLLA) fillers like Sculptra are renowned for their gradual collagen stimulation. Unlike fillers that offer immediate volume, PLLA works over time, laying the groundwork for fibroblasts to rebuild the skin’s collagen matrix. This process unfolds over several months, with patients noticing a progressive improvement in skin firmness and a reduction in wrinkles. The subtlety of this approach allows for a more natural-looking enhancement, aligning with the body’s own pace of rejuvenation.

Polycaprolactone (PCL)

Brand Names (e.g., Ellansé): Ellansé is a leading brand name within the polycaprolactone (PCL) category, distinguished by its unique ability to offer both immediate correction and long-term collagen stimulation. As a biostimulatory filler, Ellansé provides an initial sculpting effect, followed by a prolonged phase of collagenesis. This dual-action not only enhances facial contours but also improves skin quality, making it a comprehensive solution for age-related changes.

Longevity and Collagen Stimulation: The longevity of PCL-based fillers like Ellansé is one of their most compelling attributes. By stimulating collagen production, these fillers ensure that the skin’s structural integrity is reinforced from within. Patients can enjoy the rejuvenating effects for up to four years, a significant advantage over other non-permanent fillers. This extended duration not only offers convenience but also contributes to a sustained youthful appearance.

Other Biostimulatory Injectables

Platelet-Rich Plasma (PRP): PRP therapy harnesses the healing power of a patient’s own blood. Concentrated platelets and growth factors, derived from the blood, are injected into the skin to stimulate tissue repair and collagen production. This natural approach to skin rejuvenation is particularly effective for improving skin texture, reducing fine lines, and accelerating the healing process post-procedure.

Platelet-Rich Fibrin (PRF): PRF is an advanced form of PRP that contains a higher concentration of platelets, leukocytes, and fibrin. When injected, it releases growth factors over a longer period, promoting more sustained collagen production and tissue regeneration. PRF treatments are gaining popularity for their efficacy in enhancing skin quality, promoting hair growth, and supporting wound healing with minimal risk of adverse reactions.

The Treatment Process

The treatment process for biostimulatory fillers is a meticulous journey from consultation to post-treatment care, ensuring patient safety and optimal results.

Consultation and Assessment

The initial consultation and assessment are very important steps in the treatment process with biostimulatory fillers. During this phase, the practitioner evaluates the patient’s skin condition, discusses aesthetic goals, and determines the most suitable treatment plan. This personalized approach is crucial for addressing specific concerns and achieving natural-looking results. The assessment also includes a review of medical history and a discussion of potential risks and benefits, laying the groundwork for a successful treatment experience.

Injection Techniques

Needle vs. Cannula: The choice between using a needle or a cannula for biostimulatory filler injections is an important consideration in the treatment process. Needles allow for precise placement of the filler and are often used for deeper injections. Cannulas, on the other hand, have a blunt tip and are flexible, which can minimize bruising and discomfort. The decision between the two will depend on the treatment area, the type of filler used, and the practitioner’s expertise.

Depth of Injection: The depth of injection is a critical factor in the administration of biostimulatory fillers. It can influence the effectiveness of the treatment and the longevity of the results. Superficial injections may be suitable for fine lines and skin quality improvements, while deeper injections are necessary for restoring volume and contouring. The practitioner’s knowledge of facial anatomy and the filler’s properties will guide the appropriate depth for each treatment area.

Number of Sessions Required

The number of sessions required for biostimulatory filler treatments varies depending on the individual’s skin condition, the area being treated, and the desired outcome. Typically, an initial series of treatments spaced several weeks apart is necessary to achieve optimal collagen stimulation and volume restoration. Maintenance sessions may be recommended annually or biannually to preserve the rejuvenating effects and support the skin’s ongoing collagen production.

Combination Treatments

Biostimulatory Fillers with HA Fillers: Combining biostimulatory fillers with hyaluronic acid (HA) fillers can address a broad spectrum of aging signs by providing both immediate and long-term improvements. HA fillers offer instant volume and hydration, while biostimulatory fillers work gradually to rebuild the skin’s collagen framework. This synergistic approach can lead to enhanced results, with HA fillers providing the initial correction and biostimulatory fillers ensuring sustained rejuvenation.

Biostimulatory Fillers with Energy-Based Devices: Integrating biostimulatory fillers with energy-based devices like lasers or radiofrequency can further enhance skin quality and tightening. Energy-based treatments can improve skin texture, tone, and elasticity, complementing the volumizing and collagen-stimulating effects of biostimulatory fillers. This combination can lead to a more comprehensive anti-aging strategy, targeting both superficial skin concerns and deeper structural changes.

Frequently Asked Questions

How do I know if I'm a good candidate for biostimulatory fillers?

Good candidates for biostimulatory fillers are those looking to address signs of aging, such as volume loss and wrinkles, and who desire long-term improvement in skin quality.

Can biostimulatory fillers replace a surgical facelift?

While biostimulatory fillers can provide significant rejuvenation, they do not offer the same lifting and tightening effects as a surgical facelift.

How long does it take to see results from biostimulatory fillers?

Results from biostimulatory fillers can be seen gradually over several months as the body produces new collagen.

Are biostimulatory fillers safe?

Biostimulatory fillers are generally safe when administered by a qualified provider, with a risk profile similar to other injectable treatments.

Can biostimulatory fillers be reversed or dissolved?

Unlike hyaluronic acid fillers, biostimulatory fillers cannot be easily reversed or dissolved.

How much do biostimulatory filler treatments cost?

The cost of biostimulatory filler treatments varies depending on the type of filler, the number of sessions required, and the provider's fees.

Can I combine biostimulatory fillers with other aesthetic treatments?

Yes, biostimulatory fillers can be combined with other aesthetic treatments for a comprehensive approach to facial rejuvenation.

How often do I need to get biostimulatory filler treatments?

After the initial series of treatments, maintenance sessions are typically recommended every 1-2 years.

Are there any long-term side effects associated with biostimulatory fillers?

Long-term side effects are rare, but as with any medical procedure, there are potential risks which should be discussed with your provider.


Biostimulatory fillers offer a promising path for those seeking to rejuvenate their appearance with results that evolve naturally and last longer than traditional fillers. With a variety of options available, adapted to address specific aging concerns, these fillers represent a significant advancement in aesthetic medicine. As with any cosmetic procedure, the key to success lies in selecting a qualified provider and understanding the treatment process, including pre- and post-care, to ensure safety and satisfaction with the results.

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Haddad, S., Galadari, H., Patil, A., Goldust, M., Al Salam, S., & Guida, S. (2022). Evaluation of the biostimulatory effects and the level of neocollagenesis of dermal fillers: a review.

Nowag, B., Schäfer, D., Hengl, T., Corduff, N., & Goldie, K. (2024). Biostimulating fillers and induction of inflammatory pathways: A preclinical investigation of macrophage response to calcium hydroxylapatite and poly-L lactic acid.

Dr. Aurora Kalmanson

Always Consult a Medical Specialist

The information provided in this blog is for informational and educational purposes only and should not be interpreted as personalized medical advice. It's crucial to understand that while we are medical professionals, the insights and advice we provide are based on general research and studies. They are not tailored to individual health needs or conditions. Thus, it is essential to consult directly with a healthcare provider who can offer personalized medical advice relevant to your specific situation.