Best Filler for Nasolabial Folds – Make the Right Choice

Medically Reviewed
Medically Reviewed by Dr. Aurora Kalmanson on
Written by Fillers Editorial Team, plastic surgery specialists.

Discovering the most effective dermal filler for nasolabial folds can transform the way you address the signs of aging around your mouth and nose. While various treatments are available, hyaluronic acid (HA) fillers stand out for their effectiveness and versatility in smoothing out these prominent facial lines.

With the right filler, adapted to the severity of the folds and individual skin characteristics, you can achieve a natural and rejuvenated appearance.

Choosing the Best Filler for Nasolabial Folds

Finding the ideal filler hinges on evaluating numerous factors tied to one’s personal aging process and expectations, delivering an adapted solution for nasolabial folds.

Factors to Consider

Depth and Severity of Nasolabial Folds: Analyzing the depth and severity of nasolabial folds is vital when selecting a suitable filler. Lighter folds may benefit from softer, more fluid fillers that offer a subtle smoothing effect, while deep, pronounced folds may require fillers with robust volumizing capabilities. The correct choice relies on a meticulous examination of the facial structure and the fold’s characteristics, ensuring the filler not only fills the crease but also complements the overall harmony of the face. Aesthetic goals, whether they lean towards a discreet refinement or a more noticeable restoration, will also influence the filler chosen to collaborate with the natural aging process.

Desired Longevity of Results: When deciding on a filler treatment, it’s not just about the immediate improvement—considering the longevity of results is equally important. Fillers come with varied life spans; some are temporary, calling for frequent touch-ups, while others preserve the enhanced look for up to two years. Patients must weigh the commitment of maintenance appointments against the convenience of longer-lasting alternatives. Longevity also interacts with lifestyle and metabolic rate—factors that can affect the rate at which one’s body metabolizes the filler, thus shaping the treatment plan and the expectations of results duration.

Patient’s Age and Skin Condition: The effectiveness of a filler is significantly influenced by the patient’s age and the condition of their skin. Younger skin, with its higher elasticity and collagen levels, might respond well to a lighter touch, whereas mature skin with pronounced volume loss or elasticity diminishment might benefit from fillers with a stronger structural support or collagen-stimulating properties. It’s also essential to consider the skin’s texture and tone, as these aspects can affect the final outcome. By considering these individual variables, the chosen filler can complement the patient’s unique features and offer a natural, age-appropriate refreshment.

Comparison of Popular Fillers for Nasolabial Folds

Juvederm Vollure vs. Juvederm Ultra Plus: When exploring solutions for nasolabial folds, Juvederm Vollure and Juvederm Ultra Plus are frequently considered. Vollure, adapted for moderate to severe creases, utilizes Vycross technology allowing prolonged duration up to 18 months. This technology gives Vollure the flexibility to accommodate dynamic facial expressions. On the other hand, Juvederm Ultra Plus is designed to target deeper folds and restore volume with a thicker consistency. Despite being a potent volumizer, Ultra Plus tends to have a shorter lifespan, with results typically lasting up to 12 months. Patients seeking longevity and natural movement might prefer Vollure, while those desiring significant volume enhancement might opt for Ultra Plus, showcasing the necessity to match product attributes with patient-specific aesthetic goals.

Restylane Defyne vs. Restylane Refyne: In the Restylane product line, Defyne and Refyne both aim to correct nasolabial folds with subtle differences. Restylane Defyne, created for deeper folds and facial volume deficits, offers a robust framework that supports expressive areas while maintaining a natural feel. Refyne, on the other hand, is finer and intended for mild to moderate lines, providing a softer finish and mild lifting effect. Both products benefit from XpresHAn Technology, known for exceptional integration with the skin, but the choice between Defyne and Refyne hinges on the depth of the concerns and the desired aesthetic. Personal preferences, such as the extent of correction or preservation of facial dynamics, play a crucial role in this decision.

Radiesse vs. Sculptra: The choice between Radiesse and Sculptra centers on the desired approach to treating nasolabial folds. Radiesse offers immediate correction through a mix of calcium hydroxylapatite microspheres, also stimulating collagen production for dual-acting longevity that can last 12 to 18 months. Sculptra works distinctly, gradually prompting the skin to generate collagen over an extended period, thereby creating a more sustained solution for volume loss and enhancing facial contour. The outcomes of Sculptra unfold over several months but can last beyond two years. The decision between Radiesse and Sculptra involves evaluating the immediacy of results, duration, and the biological process behind the treatment.

Importance of Consultation with a Qualified Injector

Opting for injectable treatments for nasolabial folds requires consultation with a skilled injector. This expert will perform an in-depth facial analysis, discuss potential outcomes, and adapt the treatment to individual facial anatomy and desired results. The expertise of the injector is crucial in selecting the appropriate filler, technique, and the precise amount needed. A nuanced understanding of facial structure and experience with various filler consistencies lead to more refined, natural-looking outcomes. A specialized injector also recognizes the importance of aligning patient expectations with the practical possibilities of the treatment, thereby ensuring satisfaction and promoting aesthetic harmony.

Complementary Treatments for Nasolabial Folds

Beyond dermal fillers, a variety of treatments can synergize to attenuate nasolabial folds for a comprehensive facial revitalization.

Botulinum Toxin (Botox) Injections

Botulinum toxin injections, commonly known as Botox, can serve as an adjunct to fillers for addressing nasolabial folds. While not directly filling the fold, Botox works by relaxing the underlying muscles that contribute to facial expressions that deepen these lines. Strategic application of Botox around the mouth and nose can slow the progression of nasolabial folds, complementing the volumizing effect of dermal fillers. The key is a conservative approach, as the area around the mouth is dynamic and requires a delicate balance to preserve natural movement and expression. Injectors with a complex understanding of facial anatomy can use this combination therapy to achieve a subtle yet effective rejuvenation, often extending the benefits of fillers.

Skin Resurfacing Treatments

Laser Resurfacing: Laser resurfacing is an advanced skin rejuvenation treatment that targets the superficial and deeper layers of the skin. Utilizing concentrated light beams, this technique can precisely remove old, damaged skin cells, stimulating the body’s natural healing process and promoting new collagen production. For nasolabial folds, fractional laser resurfacing can improve skin texture and resilience, leading to a softening of these folds and an overall rejuvenated appearance. The treatment intensity and downtime vary with the specific laser used, making a thorough consultation with a skincare specialist crucial to determining the best approach for each individual’s skin type and condition.

Chemical Peels: Chemical peels represent a time-honored skincare procedure that accelerates skin exfoliation, revealing fresh, more youthful skin beneath. Through the application of a chemical solution, the outermost layers of the skin are gently thrown away, diminishing superficial signs of aging such as minor nasolabial fold visibility and skin texture irregularities. Peels range from mild, requiring no downtime, to more intense formulations that significantly retexture the skin over a longer recovery period. Regularly scheduled chemical peels can support the results of fillers by enhancing skin quality, boosting collagen, and maintaining a supple, youthful complexion.

Combining Fillers with Other Treatments for Complete Rejuvenation

Embracing a holistic approach that combines fillers with other non-surgical treatments can lead to superior facial rejuvenation. By pairing dermal fillers specifically designed to target the volume loss contributing to nasolabial folds with modalities such as Botox, laser resurfacing, or chemical peels, one can achieve a more refined and global anti-aging effect. This strategy addresses multiple facets of aging, such as skin laxity, surface texture, and dynamic lines, offering a full spectrum of improvements. A skilled injector will form a customized treatment plan that takes advantage of the strengths of each procedure, ensuring natural-looking results that enhance the individual’s unique features.

Frequently Asked Questions

How long does it take to see results from nasolabial fold fillers?

Results from nasolabial fold fillers are typically seen immediately after the treatment, with optimal outcomes visible once any swelling subsides, usually within a few days to a week.

Can nasolabial fold fillers be reversed if I'm not satisfied with the results?

Yes, fillers made of hyaluronic acid can often be dissolved with an enzyme called hyaluronidase, allowing for reversal if you are not satisfied with the results.

Are there any long-term side effects associated with nasolabial fold fillers?

Long-term side effects from nasolabial fold fillers are rare but can include granuloma formation, asymmetry, and, in very rare cases, skin necrosis or vascular complications.

Can nasolabial fold fillers be combined with other facial rejuvenation treatments?

Absolutely, nasolabial fold fillers can be effectively combined with treatments like Botox, laser resurfacing, or chemical peels for a more comprehensive approach to facial rejuvenation.


The journey to soften nasolabial folds through fillers promises both immediate improvement and enduring grace. With a rich array of options, and the guidance of a skilled injector, each person can embrace an adapted treatment, maintaining the delicate balance between renewal and natural expression.

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Abdulbaky, A. H. I., & Wong, V. (2024). Treatment of the Nasolabial Fold Using a Hyaluronic Acid-Based Filler with eXcellent Three-Dimensional Reticulation (XTR™) Technology: A Retrospective Study.

Stefura, T., Kacprzyk, A., Droś, J., Krzysztofik, M., Skomarovska, O., Fijałkowska, M., & Koziej, M. (2021). Tissue Fillers for the Nasolabial Fold Area: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.

Dr. Aurora Kalmanson

Always Consult a Medical Specialist

The information provided in this blog is for informational and educational purposes only and should not be interpreted as personalized medical advice. It's crucial to understand that while we are medical professionals, the insights and advice we provide are based on general research and studies. They are not tailored to individual health needs or conditions. Thus, it is essential to consult directly with a healthcare provider who can offer personalized medical advice relevant to your specific situation.