Best Filler For Frown Lines Between Eyes: Long-Lasting Youthfulness

Medically Reviewed
Medically Reviewed by Dr. Aurora Kalmanson on
Written by Fillers Editorial Team, plastic surgery specialists.

When it comes to addressing the pesky frown lines between the eyes, also known as glabellar lines, the best approach often involves a combination of treatments. While hyaluronic acid (HA) fillers are a popular choice for their immediate plumping effect and compatibility with the body, they are not the only option.

In some cases, a neuromodulator like Botox may be more appropriate to relax the muscles that contribute to these lines. The choice of treatment should be adapted to the individual’s needs, considering factors such as the depth of the lines, skin type, and desired outcome. Consulting with a qualified professional is crucial to determine the most effective and safe treatment plan.

Choosing the Best Filler for Frown Lines

Selecting the right filler for frown lines is a decision that should be made with careful consideration of various factors, ensuring a treatment that aligns with the individual’s aesthetic goals.

Factors to Consider

Severity of Frown Lines: The severity of frown lines is a primary factor in choosing the appropriate filler. For mild to moderate lines, hyaluronic acid fillers may suffice, offering a smooth and immediate correction. However, for deeper, more pronounced lines, a collagen-stimulating filler like Radiesse or Sculptra might be recommended to provide a more substantial and long-term improvement. These fillers not only fill the creases but also encourage the body to produce new collagen, leading to a gradual and natural-looking enhancement. The treatment plan should be customized to address the specific depth and characteristics of the frown lines for optimal results.

Desired Results and Longevity: When selecting a filler, it’s crucial to consider the desired outcome and how long you want the results to last. Hyaluronic acid fillers offer temporary results that typically last from six months to a year, making them suitable for those seeking a non-permanent solution or those new to fillers. On the other hand, collagen-stimulating fillers provide a longer-lasting effect, often up to two years, which may be preferable for individuals looking for a more durable solution. Discussing your expectations and maintenance preferences with a qualified professional will help determine the best filler to achieve your aesthetic goals.

Skin Type and Texture: Skin type and texture are important considerations when choosing a filler. Hyaluronic acid fillers are generally well-tolerated by all skin types and are effective in adding volume and hydration to the skin, making them a versatile choice. For those with thicker skin or more significant volume loss, collagen-stimulating fillers may offer a better structure and support. Additionally, the condition of the skin, such as its elasticity and the presence of scars or other textural irregularities, can influence the selection of the filler. A thorough assessment of the skin’s characteristics can guide the choice of the most suitable filler to enhance the skin’s overall appearance.

Budget and Cost-Effectiveness: Budget is an essential factor in the decision-making process for cosmetic treatments. While hyaluronic acid fillers may have a lower upfront cost, their shorter duration means that repeated treatments will be necessary to maintain the results, which could lead to higher long-term expenses. Collagen-stimulating fillers, although potentially more costly initially, may offer better cost-effectiveness over time due to their longevity. It’s important to consider not only the price per syringe but also the total investment over time, including the potential need for touch-up treatments. A cost-benefit analysis, in consultation with a qualified injector, can help determine the most economical approach to achieving and maintaining the desired aesthetic outcome.

Comparison of Filler Properties

Longevity: The longevity of a filler is a critical factor for patients seeking to maintain their youthful appearance with minimal maintenance. Hyaluronic acid fillers, while providing immediate results, typically last from six months to a year before being naturally absorbed by the body. In contrast, collagen-stimulating fillers like Radiesse and Sculptra offer longer-lasting effects, with results that can endure for a year or more. The extended duration is due to these fillers’ ability to stimulate the body’s own collagen production, leading to a gradual and sustained improvement in skin quality and structure.

Texture and Consistency: The texture and consistency of fillers play a significant role in determining their suitability for different areas of the face and types of wrinkles. Hyaluronic acid fillers are known for their smooth gel-like consistency, which allows for a natural feel and is ideal for areas requiring subtle enhancement. Collagen-stimulating fillers, on the other hand, have a thicker consistency due to their composition, which includes microspheres or particles that provide immediate volume and stimulate collagen production. The choice between these fillers will depend on the patient’s specific needs, the severity of the wrinkles, and the desired outcome.

Injection Depth: Injection depth is a pivotal aspect of filler treatments, influencing both the effectiveness and safety of the procedure. Hyaluronic acid fillers are typically injected into the mid to deep dermis, depending on the product’s viscosity and the area being treated. Collagen-stimulating fillers, such as Radiesse and Sculptra, are injected deeper into the dermis or subcutaneous layer to provide a robust framework for collagen growth. The depth of injection is carefully selected by the practitioner based on the filler’s properties and the patient’s skin condition to ensure optimal results and minimize the risk of complications.

Combining Fillers with Other Treatments

Combining fillers with other cosmetic treatments can enhance overall facial rejuvenation, addressing a range of concerns from fine lines to volume loss.

Botulinum Toxin Injections (Botox, Dysport, Xeomin)

Mechanism of Action: Botulinum toxin injections, commonly known as Botox, Dysport, and Xeomin, work by temporarily paralyzing the targeted facial muscles. These neuromodulators block the nerve signals that cause muscle contractions, leading to a reduction in the appearance of dynamic wrinkles caused by facial expressions. The treatment is highly effective for frown lines, crow’s feet, and forehead lines. The onset of action typically occurs within a few days, with the peak effect visible at around two weeks. The results can last anywhere from three to six months, after which the muscle activity gradually returns, and the lines may reappear.

Synergistic Effects with Fillers: The combination of botulinum toxin injections with dermal fillers can produce synergistic effects, enhancing the overall aesthetic outcome. While fillers add volume and smooth out static wrinkles, botulinum toxin injections address the muscle activity that contributes to dynamic wrinkles. This dual approach can lead to a more comprehensive rejuvenation, as it tackles both the underlying muscle movements and the visible signs of aging. By using these treatments in conjunction, patients can achieve a more youthful and refreshed appearance with results that are both significant and natural-looking.

Laser Resurfacing

Improving Skin Texture and Tone: Laser resurfacing is a powerful technique for enhancing skin texture and tone, addressing issues such as fine lines, wrinkles, scars, and uneven pigmentation. The procedure involves the use of concentrated light beams to remove the outer layers of damaged skin, promoting the growth of new, healthy skin cells. As the treated area heals, patients notice a significant improvement in the smoothness and evenness of their skin’s surface. The precise nature of laser resurfacing allows for targeted treatment, making it an effective option for those looking to rejuvenate their complexion and achieve a more radiant, youthful appearance.

Microneedling and Platelet-Rich Plasma (PRP) Therapy

Microneedling, often combined with Platelet-Rich Plasma (PRP) therapy, is a minimally invasive treatment that stimulates the skin’s natural healing processes. The procedure involves creating micro-injuries on the skin’s surface using fine needles, which triggers the production of collagen and elastin. When paired with PRP, which is derived from the patient’s own blood and contains growth factors, the treatment’s regenerative effects are enhanced. This synergistic approach can lead to improved skin texture, reduced scarring, and a more youthful appearance. The versatility of microneedling with PRP makes it suitable for a wide range of skin types and concerns, offering a customizable solution for skin rejuvenation.

Frequently Asked Questions

Can fillers be used preventatively for frown lines?

Yes, fillers can be used preventatively to smooth out early signs of frown lines and delay their deepening.

Are there any age restrictions for getting fillers for frown lines?

Fillers for frown lines are typically recommended for adults over the age of 21, but there are no strict age restrictions. It's best to consult with a qualified injector.

Can fillers be combined with Botox for better results?

Yes, combining fillers with Botox can provide better results by addressing both volume loss and muscle activity that contribute to frown lines.

Are there any natural remedies or exercises to reduce frown lines?

While natural remedies and facial exercises may provide some benefit, they are generally less effective than professional treatments like fillers.

Will filler injections make my frown lines look unnatural or "frozen"?

When performed by an experienced injector, filler injections should provide natural-looking results without a "frozen" appearance.


In conclusion, fillers offer a dynamic solution for softening frown lines and rejuvenating the face. With a range of products available, adapted treatments can address individual concerns and enhance one's natural features. While the results are not permanent, maintenance treatments can prolong the benefits. It's essential to consult with a qualified injector to ensure safety and achieve the desired outcome.

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Tansatit, T., Uruwan, S., & Rungsawang, C. (2021). The Crest Injection Technique for Glabellar Line Correction and the Paracentral Artery.

Carruthers, A., Carruthers, J., De Boulle, K., Lowe, N., Lee, E., & Brin, M. F. (2023). Treatment of crow's feet lines and forehead lines with Botox (onabotulinumtoxinA): Development, insights, and impact.

Dr. Aurora Kalmanson

Always Consult a Medical Specialist

The information provided in this blog is for informational and educational purposes only and should not be interpreted as personalized medical advice. It's crucial to understand that while we are medical professionals, the insights and advice we provide are based on general research and studies. They are not tailored to individual health needs or conditions. Thus, it is essential to consult directly with a healthcare provider who can offer personalized medical advice relevant to your specific situation.