Best Dermal Fillers for Over 50: What are Your Options?

Medically Reviewed
Medically Reviewed by Dr. Aurora Kalmanson on
Written by Fillers Editorial Team, plastic surgery specialists.

Aging gracefully is the goal, and dermal fillers offer a strategic line of defense against the markers of time for those over 50. Whether you’re looking to soften smile lines, lift marionette lines, or enhance facial volume, injectables can be adapted to address specific concerns with minimal downtime.

Recent advances offer a range of formulas from hyaluronic acid favorites like Juvederm and Restylane, to longer-lasting options such as Radiesse and Sculptra, designed with the unique needs of mature skin in mind. For those seeking an aesthetic refresh, the best filler is one that harmonizes with your features, aligns with your lifestyle, and is administered by a seasoned professional.

Best Dermal Fillers for Specific Areas in the 50s

Approaching fillers in your 50s requires a targeted strategy. Identifying which facial areas you’d like to enhance is the first step, since products vary in consistency and longevity. The goal is to replenish lost volume and smooth out lines for a refreshed look that still feels like you.

Nasolabial Folds (Smile Lines)

Recommended Fillers (Juvederm, Restylane, etc.): Treatments for nasolabial folds often employ hyaluronic acid-based fillers like Juvederm or Restylane, which integrate smoothly into the skin for natural-looking results. These gels plump up the creases that deepen with age, stretching from the nose to the corners of the mouth. The subtle lift they provide can shave years off one’s appearance. The chosen brand and product line will depend on the individual’s skin condition, the depth of their folds, and their personal preferences, which can be best evaluated during a consultation with a qualified provider.

Expected Results and Longevity: Dermal fillers in the nasolabial region can revitalize the lower face, smoothing out the smile lines and giving a more youthful contour. The results from hyaluronic acid fillers typically last anywhere from 6 to 18 months, depending on the specific product used and the body’s metabolism rate. To maintain results, follow-up treatments can be scheduled once the effects begin to wane, allowing for continuous enjoyment of a revitalized appearance.

Marionette Lines

Recommended Fillers (Radiesse, Sculptra, etc.): Marionette lines, which frame the chin and create a downturned expression, respond well to robust fillers like Radiesse and Sculptra. Radiesse, with its calcium hydroxyapatite composition, offers immediate volume addition while stimulating natural collagen production for durable results. Sculptra, on the other hand, uses poly-L-lactic acid to gradually restore facial volume. As a collagen stimulator, Sculptra performs over time, enhancing the skin’s structure and smoothing out marionette lines for a subtle, enduring effect.

Both Radiesse and Sculptra present viable options for individuals over 50 looking to rejuvenate the lower facial area with considerations such as longevity, natural appearance, and overall enhancement of skin quality guiding the choice of filler.

Expected Results and Longevity: For addressing marionette lines, the fillers provide both instant correction and long-term improvements. Radiesse and Sculptra, specifically, not only fill but also stimulate collagen, lending a dual-action approach to fortifying skin’s elasticity and structure. The effects of Radiesse can typically be seen for about 12 to 18 months, making it a favored choice for lasting rejuvenation. Sculptra, aiming for a more gradual change, offers subtle refinement over a few months with results that can last up to two years. Both fillers empower individuals over 50 to maintain their aesthetic improvements with minimal maintenance.

Cheeks and Midface

Recommended Fillers (Juvederm Voluma, Restylane Lyft, etc.): Midface volume loss is elegantly managed with robust fillers like Juvederm Voluma and Restylane Lyft. These fillers are designed with a thicker consistency, suitable for deeper injections into areas with denser tissue such as the cheeks. Adding volume to the midface not only restores youthful contours but also indirectly elevates the lower face, mitigating nasolabial fold prominence. Tailored to withstand the dynamic expressions of the midface, these hyaluronic acid dermal fillers blend smoothly into the tissue, providing natural lift and defying gravity’s pull.

Expected Results and Longevity: The transformative effect of fillers such as Juvederm Voluma and Restylane Lyft on the cheeks and midface is both immediate and enduring. Voluma showcases one of the longest-lasting results in the sphere of hyaluronic acid fillers, promising to enhance facial architecture for up to 24 months. Similarly, Restylane Lyft delivers a noticeable lift, with results that can last approximately 12 months. Optimal for those seeking substantial, lasting rejuvenation, these fillers offer the promise of prolonged youthfulness, with touch-ups as needed to maintain the uplifted aesthetic.

Lips and Perioral Area

Recommended Fillers (Juvederm Volbella, Restylane Silk, etc.): The search for subtle lip enhancement finds its allies in fillers like Juvederm Volbella and Restylane Silk. Designed specifically for the delicate lip tissue, these products excel at adding volume, smoothing vertical lip lines, and defining the lip border without overstatement. Juvederm Volbella and Restylane Silk harbor smoother formulations that integrate into the soft tissue, enabling a natural look that complements the overall visage.

Expected Results and Longevity: Dermal fillers for the lips and perioral area perform with finesse, offering instant gratification with results that are tastefully understated. Juvederm Volbella and Restylane Silk, while adept at creating a plump, hydrated look, fulfill the modern desire for subtlety, with effects that typically last around 6 to 12 months. As with all hyaluronic acid-based products, longevity can fluctuate with individual metabolism and lifestyle factors, but the fillers’ hygroscopic nature helps maintain lip suppleness and contour definition over time. Regular treatments can sustain the desired lip aesthetics, smoothly blending into a comprehensive anti-aging regimen.

Long-Lasting Dermal Fillers for the 50s

In the realm of anti-aging treatments, long-lasting dermal fillers are the crown jewels for individuals in their 50s, meticulously designed to cater to deeper wrinkles and facial volume restoration. These options provide enduring results, minimize frequent visits for maintenance, and ensure a consistent, youthful appearance that transcends the temporary.


Unique Collagen-Stimulating Properties: Bellafill stands out with its dual-action approach. Its primary component, polymethyl methacrylate (PMMA) microspheres, remains beneath the skin indefinitely, providing a permanent framework for collagen growth. This fosters natural tissue development over time, offering structural support and progressive skin rejuvenation. The filler also contains collagen, which delivers immediate volume and lift. The body absorbs this collagen, but the PMMA microspheres remain, acting as beacons for the body’s own collagen, ensuring prolonged aesthetic enhancement.

Long-Term Results (Up to 5 Years): Bellafill’s reputation for longevity is well-founded. Often said to be a ‘five-year filler,’ its effect can extend up to five years, and in some cases longer, making it an appealing choice for those seeking a long haul solution. The permanence of the PMMA microspheres ensures sustained support for the skin’s structure, granting a seemingly ageless visage. However, patients should enter this treatment with a long-term commitment, as the results are not as easily reversible as other hyaluronic acid-based fillers.


Poly-L-Lactic Acid (PLLA) for Collagen Stimulation: Sculptra’s unique formulation uses PLLA, a biocompatible and biodegradable substance that acts as a collagen stimulator. Unlike conventional fillers that offer immediate volume, Sculptra works gradually, encouraging the body’s natural collagen synthesis. The treatment is strategically administered over a series of sessions, which allows for a controlled and progressive restoration of facial volume, adapted to align with each individual’s aesthetic objectives.

Gradual and Long-Lasting Results (Up to 2 Years): Sculptra sets itself apart with results that appear progressively, reflecting the natural aging process’s reverse. The gradual improvement in facial contours presents a discreet transformation, often lasting up to two years and sometimes beyond. The incremental nature of the results circumvents the abrupt change in one’s appearance, while sustained collagen production under the skin perpetuates youthful resilience. This treatment is perfect for individuals seeking to prevent signs of aging subtly and gracefully.

Frequently Asked Questions

Are dermal fillers safe for people over 50?

Dermal fillers are widely considered safe for people over 50, with appropriate assessment and administration by a qualified professional. However, individual health conditions should always be discussed during the consultation.

How often should I get dermal filler treatments?

The frequency of dermal filler treatments varies, depending on the type of filler used, the area treated, and individual factors. On average, treatments may be repeated every 6 to 18 months.

Can dermal fillers replace a surgical facelift?

Dermal fillers cannot replace the comprehensive results of a surgical facelift; however, they can significantly improve the appearance of wrinkles and lost volume with less downtime and lower cost.

How much do dermal filler treatments cost?

The cost of dermal filler treatments can vary widely based on the type of filler, area of treatment, geographic location, and practitioner's expertise. It's best to consult with a provider for specific pricing.

Is there any downtime after dermal filler injections?

Most dermal filler injections involve minimal downtime, allowing patients to return to daily activities shortly after the procedure. Some minor swelling or bruising may occur.


Navigating the world of dermal fillers can be complex, yet understanding the nuances can lead to successful and satisfying cosmetic enhancements. By harmonizing treatment plans with individual goals, accommodating personal health profiles, and carefully considering each filler's unique properties, individuals over 50 can achieve refined, natural-looking rejuvenation. These carefully crafted treatments, when overseen by qualified professionals, can allow for a graceful transition through the decades, all the while championing the beauty of aging with confidence.

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Akinbiyi, T., Othman, S., Familusi, O., Calvert, C., Card, E. B., & Percec, I. (2020). Better Results in Facial Rejuvenation with Fillers.

Brandt, F. S., & Cazzaniga, A. (2008). Hyaluronic acid gel fillers in the management of facial aging.

Dr. Aurora Kalmanson

Always Consult a Medical Specialist

The information provided in this blog is for informational and educational purposes only and should not be interpreted as personalized medical advice. It's crucial to understand that while we are medical professionals, the insights and advice we provide are based on general research and studies. They are not tailored to individual health needs or conditions. Thus, it is essential to consult directly with a healthcare provider who can offer personalized medical advice relevant to your specific situation.